Spindlecheckpoint

The mitotic checkpoint or spindle assembly checkpoint is an evolutionarily conserved mechanism that ensures that cells with misaligned chromosomes do not ...

The spindle assembly checkpoint (SAC) is an active signal produced by improperly attached kinetochores, which is conserved in all eukaryotes. The SAC stops the ...

由 GJ Gorbsky 著作 · 2015 · 被引用 100 次 — The spindle checkpoint is a key regulator of chromosome segregation in mitosis and meiosis. Its function is to prevent precocious anaphase ...

由 N London 著作 · 2014 · 被引用 350 次 — The spindle checkpoint signalling cascade prevents anaphase onset until all chromosomes are correctly attached, through their kinetochores, ...

由 A Musacchio 著作 · 2002 · 被引用 711 次 — It monitors the interactions between chromosomes and microtubules, and delays mitotic progression to allow extra time to correct defects. Here, ...

由 GJ Gorbsky 著作 · 2015 · 被引用 100 次 — The spindle checkpoint is a key regulator of chromosome segregation in mitosis and meiosis. Its function is to prevent precocious anaphase onset before ...

由 P Lara-Gonzalez 著作 · 2021 · 被引用 112 次 — The spindle assembly checkpoint (SAC) is a surveillance mechanism that promotes accurate chromosome segregation in mitosis. The checkpoint senses the ...

由 P Lara-Gonzalez 著作 · 2012 · 被引用 915 次 — During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate ...

The spindle checkpoint or mitotic checkpoint is a cell cycle checkpoint that delays the segregation until all chromosomes are correctly attached to the mitotic ...